ANTIOXIDANT PROPERTIES OF POLYALTHIA CERASOIDES STEM BARK EXTRACT ON STREPTOZOTOCIN INDUCED DIABETIC RATS.
Bhargavi G, Josthna P and Naidu CV*
ABSTRACT
The present study was to evaluate the antioxidant properties of ethanolic extract of Polyalthia cerasoides stem bark (PcEE) on streptozotocin induced diabetic rats. Diabetes was induced by single intra peritoneal injection at a dose 45mg/kg body weight. The rats were randomly divided into five groups (n=6). Group I and II (normal and diabetic controls), Group III (normal rats fed with 400 mg of PcEE), Group IV (diabetic rats fed with 400mg of PcEE), Group V (diabetic rats fed with 20 mg of Glibinclamide). PcEE was administered to the rats at a dose 400mg/kg body weight for 21 days. Tissues were collected after the 21 days treatment. The antioxidant activity of extract was evaluated by measuring the activity of enzymes sush as Catalase, Superoxide dismutase (SOD), Glutathione peroxidise (GPX), Glutathione reductase (GR) and Glutathione S-transeferase (GST) in liver and kidney of normal and diabetic treated animals. These enzyme levels in diabetic rats were decreased compared to normal rats. Administration of ethanolic extract of P. cerasoides stem bark were significantly (P <0.01) increased the antioxidant enzyme levels in both liver and kidney of STZ induced diabetic treated rats. Our results clearly suggest that the PcEE was effectively normalizing the impaired antioxidant levels in STZ induced diabetic rats as effective as glibinclamide treated diabetic rats. The extract shows rapid protective effect against lipid peroxidation by scavenging the free radicals. The experimental results may give the pharmacological support for the use P.cerasoides stem bark in management of diabetes mellitus.
Keywords: Diabetes mellitus, Hyperglycemia, Streptozotocin, Oxidative stress, Glibinclamide, Antioxidant enzymes.
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