FORMULATION DEVELOPMENT AND EVALUATION OF BILAYER TABLET OF ARTEMETHER BY USING NATURAL BIOENHANCER FOR THE TREATMENT OF MALARIAL PARASITES
A. Y. Joshi*, A. B. Darekar, R. B. Saudagar
ABSTRACT
The aim of present study is to formulate Artemether sustained release (SR) and immediate release (IR) bilayer tablet by different concentration of Hydroxypropyl methylcellulose (HPMC) and PVP K 30 M to control the release pattern. The sustained release layer of Artemether was prepared by using HPMC and PVP K 30 along with other excipients by direct compression technique. The immediate release layer of Artemether was prepared by Cross carmellose sodium and Sodium starch glycolate by direct compression technique. The powders were evaluated for their flow properties and the finished tablets were evaluated for their physical parameters. The both immediate release and sustained release layers of Artemether were characterized by FT-IR and in vitro dissolution studies. The drug release study of Artemether was evaluated using USP-II paddle type dissolution apparatus. The release rate of Artemether in immediate release layer was studied for 1h in 0.1 N HCL media and that of Artemether in sustained release layer was studied for 12 h in pH 6.8 phosphate buffer media. From the nine batches S5 batch showed good release behaviour 94.92% of drug is released over 12 hours. Artemether is a poorly water soluble (BCS class 4) antimalarial drug. Due to the poor water solubility of this drug, its bioavailability is dissolution rate-limited., the stability studies of the products also comply with ICH guideline.
Keywords: Bi-layer tablet, Sustained Release, Immediate Release, Artemether.
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