ASSESSMENT OF LIPIDS PROFILE IN SUDANESE LEUKEMIC PATIENTS
Nahla I. Ibrahim, Sohair A. M, Gadalla Modawe, *AbdElkarim A. Abdrabo
ABSTRACT
Background: A number of studies have been published in recent years
showing a significant association between leukemia and low plasma
cholesterol levels. Objectives: We measured lipids profile which
includes plasma total cholesterol, low density (LDL) and high density
(HDL) lipoproteins in patients with leukemia in comparison with age
and sex matched controls. Materials and Methods: The study
included 50 normal healthy controls and 100 patients with leukemia
(64 acute and 36 of them are chronic). Cholesterol profile was estimated using
spectrophotometer method. Results: Mean ± SD of total cholesterol, LDL and HDL in
leukemic patients were (120.86 ± 23.04, 29.47 ± 10.76, 29.38 ± 8.45mg/dl) respectively,
while the mean ± SD of healthy person were (168.00 ± 14.73, 61.94 ± 14.64, 62.50 ±
10.60mg/dl) respectively. This result show highly significant difference which was lower in
the leukemic patients compared to the control with P value (0.000). Conclusion: This study
concluded that the strong association between leukemia and plasma cholesterol can be used
as markers for bad prognosis, degree of maturation of leukemic cells and follow up of
treatment. Also LDL may be used as a carrier targeting lipophilic cytotoxic drugs to leukemic
cells.
Keywords: Leukemic patients, Cholesterol, Spectrophotometer, Sudanese.
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