Abstract
ASSESSMENT OF LIPIDS PROFILE IN SUDANESE LEUKEMIC PATIENTS

Nahla I. Ibrahim, Sohair A. M, Gadalla Modawe, *AbdElkarim A. Abdrabo

ABSTRACT

Background: A number of studies have been published in recent years showing a significant association between leukemia and low plasma cholesterol levels. Objectives: We measured lipids profile which includes plasma total cholesterol, low density (LDL) and high density (HDL) lipoproteins in patients with leukemia in comparison with age and sex matched controls. Materials and Methods: The study included 50 normal healthy controls and 100 patients with leukemia (64 acute and 36 of them are chronic). Cholesterol profile was estimated using spectrophotometer method. Results: Mean ± SD of total cholesterol, LDL and HDL in leukemic patients were (120.86 ± 23.04, 29.47 ± 10.76, 29.38 ± 8.45mg/dl) respectively, while the mean ± SD of healthy person were (168.00 ± 14.73, 61.94 ± 14.64, 62.50 ± 10.60mg/dl) respectively. This result show highly significant difference which was lower in the leukemic patients compared to the control with P value (0.000). Conclusion: This study concluded that the strong association between leukemia and plasma cholesterol can be used as markers for bad prognosis, degree of maturation of leukemic cells and follow up of treatment. Also LDL may be used as a carrier targeting lipophilic cytotoxic drugs to leukemic cells.

Keywords: Leukemic patients, Cholesterol, Spectrophotometer, Sudanese.


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