Abstract
THE PHARMACODYNAMIC/PHARMACOKINETIC EVALUATION STUDY OF SERUM LEVELS OF CEFOTAXIME IN CRITICALLY ILL PATIENTS: A PILOT STUDY

Devendra Kumar Katiyar and Ravishankar Srivastav*

ABSTRACT

Introduction: Cefotaxime (CTX) is a broad-spectrum β-lactam antibiotic in the third-generation class of cephalosporins, with active against numerous Gram-positive and Gram-negative bacteria. The critically ill patient population being the most obvious choice for our study are usually prone to Nosocomial infections which are frequently acquired in the intensive care unit. This state is worrisome, if not handled and managed adequately with required dosage regime of the antibiotics. Aim: The purpose of this study was to evaluate the variability in the concentration of cefotaxime in critically ill (ICU) patients at different time intervals by grouping patients according to their site of infection and determining the number of patients in which the concentration of cefotaxime was below the minimum inhibitory concentration (MIC) and below 5 times the MIC for the isolated organism. Material and methods: It is a pilot analytical study with a sample size of 25 patients admitted to the ICU and receiving cefotaxime antibiotic, age group ranging from 20-75 yrs of age. The patients were grouped according to their Locus of infection as hepatobiliary and renal. Approximately, 2 ml of blood was withdrawn from the patients through the intravenous route at time points of 1, 2, 4, and 8 h postinfusion. Cefotaxime concentration in plasma was estimated using high-performance liquid chromatography. Then Antimicrobial susceptibility tests were performed by the disk diffusion method. Results: It was seen that the weight versus plasma concentration of cefotaxime at 1, 2, 4, and 8 h intervals did not show any significant correlation. The microorganisms were isolated and was observed that the plasma concentration of cefotaxime when compared with the hepatobiliary and the nonhepatobiliary groups, was not significant at 1h after cefotaxime dosing (P >0.05) while that between the renal and the nonrenal groups was statistically significant at all the time points {1 h (P =<0.005), 4 h (P <0.001), and 8 h (P <0.05)}. Cefotaxime concentration exceeded the MIC for most of the pathogens and Almost all patients had cefotaxime levels above 5 times the MIC for the causative organism studied except few microorganisms. Conclusion: Constant evaluation of current practice of consumption of antibiotics on basis of trends and antibiotic patterns is essential to make progress in this problematic matter. additional studies are needed on indian populatipn in future so we can slow down the emergence of antimicrobial resistance in such extremely vulnerable population of critically ill patient population.

Keywords: Cefotaxime (CTX), hepatobiliary.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: APRIL ISSUE PUBLISHED

    APRIL 2024 Issue has been successfully launched on 1 APRIL 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT