Abstract
EVALUATION OF ADVERSE DRUG REACTIONS INDUCED BY ANTI HYPERTENSIVE TREATMENT

Ravishankar Srivastav and *Devendra Kumar Katiyar

ABSTRACT

Hypertension is the medical condition where the systolic blood pressure is more than 140 mm Hg and the diastolic blood pressure is more than 90 mm Hg. It is a chronic disease which is considered to be one of the major public health problems and a significant cardiovascular risk factor. Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Achieving blood pressure goals usually requires two or more antihypertensive drugs; As the demand is increasing due to increased cases of hypertensive people , prevalence of adverse drug reactions (ADRs) has also increased. AIM: This study was aimed to monitor the adverse drug reactions (ADRs) caused by antihypertensive medicines prescribed. Materials and methods: A total of 500 patients were observed with an informed consent. ADRs experienced by patients and any other relevant history, including the pre-existing medical conditions. These ADRs were then assessed using WHO probability assessment (causality assessment) scale for adverse drug reactions. Results: A total of 42 cases of ADRs were observed in 500 hypertensive patients observed. On the causality scale of WHO, 19 (45.2%) ADRs were classified possible, 14 (33.3%) probable, 6 (14.2%) unlikely, 2(4.7%) certain and 1 (2.3%) were unclassifiable. The ADRs related to of individual drugs administered by the patients were also tabulated. Conclusion: To conclude we can say that this study gives an insight that antihypertensive drugs should be continuously monitored as they are related with many ADRs. This helps the physician in early documentation of the ADRs and this can definitely help in giood patient management.

Keywords: Hypertension is the medical in giood patient management.


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