European Journal of Biomedical and Pharmaceutical Sciences

INVESTIGATION OF WOUND HEALING ACTIVITY OF CRESSA CRETICA BY EXCISION AND INCISION METHOD

*Pragati Khare, Noopur Khare and Bharat Gupta

ABSTRACT

Objective: Cressa cretica (Convolvulaceae) is a traditional medicinal plant known as Rudanti. This plant has been used for the treatment of a variety of diseases. The plant of Cressa cretica showed antibilous, antituberculosis and expectorant, nootropic activities. Methods: This study was done to investigate the possible wound healing effects of Cressa cretica plant extract (CCE) using Excision and incision wound models. 24 swiss albino mice of either sex weighing between 25-30gm were randomly selected and divided into 4 equal groups. Group-I (control) received Control (7% HPMC gel), Group-II received Aloe vera gel (90%), III received Cressa cretica (4% HPMC gel) and Group IV received Cressa cretica (8% HPMC gel). Drug treatment was given for ten days. Results: CCE produced significant wound healing effect at dose of 4% HPMC gel & 8% HPMC gel administered for 10 days. The efficacy of CCE was found to be comparable to that of Aloe vera. Conclusion: The results of the present study indicate that CCE possesses significant wound healing activity compared to that of Aloe vera.

Keywords: Cressa cretica, excision test, incision test, Aloe vera.