European Journal of Biomedical and Pharmaceutical Sciences

ANTIUROLITHIATIC ACTIVITY OF ETHANOLIC DOLICHOS BIFLORUS LEAF EXTRACT

Pragati Khare*, Pranit Saraswat and Noopur Khare

ABSTRACT

Objective: The objective of this study is to investigate the antiurolithiatic potential of ethanolic Dolichos biflorus L. leaf extract in swiss albino mice. Methods: The antiurolithiatic potential of Dolichos biflorus L. ethanolic leaf extract was investigated by using Zinc disc foreign body insertion technique model. Antiurolithiatic activity of the leaves was evaluated on the basis of decrease in the weight of stones. 36 swiss albino mice of either sex weighing between 25-30gm were randomly selected and divided into 6 equal groups. Group-I received Prophylactic control (1% ethylene glycol for 4 weeks), Group-II received Prophylactic treatment (1% ethylene glycol + ethanolic extract of leaves of Dolichos biflorus 400 mg/kg orally for 4 weeks), Group-III received Prophylactic treatment (1% ethylene glycol + ethanolic extract of leaves of Dolichos biflorus 800 mg/ kg orally for 4 weeks), Group IV received Curative control (1% ethylene glycol for 4 weeks followed by water for 4 weeks), Group V received Curative treatment (1% ethylene glycol for 4 weeks followed by ethanolic extract of leaves of Dolichos biflorus 400 mg/kg for 4 weeks) and Group VI received Curative treatment (1% ethylene glycol for 4 weeks followed by ethanolic extract leaves of Dolichos biflorus 800 mg/kg for 4 weeks). Results: It was observed that there was significant decrease in the weight of the stones in the groups treated with leaf extract of Dolichos biflorus in comparison to the control group. Conclusion: The results of the present study indicate that ethanolic extract of Dolichos biflorus possesses significant Antiurolithiatic activity.

Keywords: Dolichos biflorus leaves, Antiurolithiatic activity, urinary bladder.