Abstract
COMPARISION OF STABILITY OF NATURAL AND SYNTHETIC SUSPENDING AGENTS IN THE FORMULATION OF SUSPENSION USING AZITHROMYCIN AS A MODEL DRUG TO MITIGATE STREP THROAT

Sai Lakshmi Jyothirmai Kala*, Supriya Palaparthi, S. S. Manikiran and N. Rama Rao

ABSTRACT

The aim of the present study is to formulate and evaluate azithromycin suspension using natural and synthetic suspending agent, and to find out the stability of natural and synthetic suspending agents in the formulation of azithromycin suspension Trigonella foenum graecum Mucilage was used as natural suspending agent. Total 10 formulations were prepared by varying concentration of suspending agent from 0.5-2% in natural suspension. Prepared suspensions were evaluated by studying different parameters like pH, sedimentation volume, redispersibility, Flow rate (F), viscosity, degree of flocculation, effect of temperature etc. batches . FN3, FN4 were found to be best among all the natural formulations, and FN4, FN5 were found to be best formulations among all the synthetic formulations. As the concentration of suspending agent increased viscosity also get increased which reduces the sedimentation and contributes to the stability of suspension. Increase in viscosity avoids the particle aggregation so particles remain in a flocculated state. The use of natural suspending agent reduced the floccules formation and increased the sedimentation volume and produced a stable suspension. Hence the use of mucilage of fenugreek seeds increased the stability of suspension.

Keywords: azithromycin, Suspension, Sedimentation volume, redispersibility, flocculation.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: JUNE ISSUE PUBLISHED

    JUNE 2024 Issue has been successfully launched on 1 JUNE 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT