COMPARISION OF STABILITY OF NATURAL AND SYNTHETIC SUSPENDING AGENTS IN THE FORMULATION OF SUSPENSION USING AZITHROMYCIN AS A MODEL DRUG TO MITIGATE STREP THROAT
Sai Lakshmi Jyothirmai Kala*, Supriya Palaparthi, S. S. Manikiran and N. Rama Rao
ABSTRACT
The aim of the present study is to formulate and evaluate azithromycin suspension using natural and synthetic suspending agent, and to find out the stability of natural and synthetic suspending agents in the formulation of azithromycin suspension Trigonella foenum graecum Mucilage was used as natural suspending agent. Total 10 formulations were prepared by varying concentration of suspending agent from 0.5-2% in natural suspension. Prepared suspensions were evaluated by studying different parameters like pH, sedimentation volume, redispersibility, Flow rate (F), viscosity, degree of flocculation, effect of temperature etc. batches . FN3, FN4 were found to be best among all the natural formulations, and FN4, FN5 were found to be best formulations among all the synthetic formulations. As the concentration of suspending agent increased viscosity also get increased which reduces the sedimentation and contributes to the stability of suspension. Increase in viscosity avoids the particle aggregation so particles remain in a flocculated state. The use of natural suspending agent reduced the floccules formation and increased the sedimentation volume and produced a stable suspension. Hence the use of mucilage of fenugreek seeds increased the stability of suspension.
Keywords: azithromycin, Suspension, Sedimentation volume, redispersibility, flocculation.
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