Abstract
OCULAR SAFETY AND TOXICITY STUDIES OF AN AYURVEDIC HERBAL EYE DROP FOR DRY EYE SYNDROME

N. Srikanth, *Sharad D. Pawar, Arjun Singh, S. N. Murthy and R.R. Padmavar

ABSTRACT

Acute Eye Irritation study of an Ayurvedic herbal eye drop containing herbal ingredients viz. Berberis aristata and Glyeyrrhiza glabra formulated for dry eye syndrome (DES ) complying the standards of Indian Pharmacopeia (IP.) was performed in New Zealand White rabbit as per the OECD guidelines for testing of chemicals (acute eye Irritation/corrosion) after fulfilling ethical requirements. 0.1 ml of the drop was placed in the conjunctival sac of one eye of each animal after gently pulling the lower lid away from the eyeball. The lids were then gently held together for about one second in order to prevent loss of the material. The other eye, which remains untreated, serves as a control. Eye drop did not cause irritation to mucous membrane of eyes of rabbits, no evident signs of toxicity and clinical changes were observed. The eye drop in New Zealand White rabbits was found to be nonirritant to the ocular mucous membrane.

Keywords: Berberis aristata, Glyeyrrhiza glabra, Acute Eye Irritation study,


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