Abstract
EVALUATION OF ALPHA-AMYLASE INHIBITORY, MEMBRANE STABILIZING & CYTOTOXIC ACTIVITIES OF Uvaria Littoralis LEAVES

*Abdullah-Al-Mamun, Muksuda Akter, Md.Ibrahim Sunny, Md. Shariful Islam, Dr. Md. Siddiqul Islam, Shakila Akter Zabin and Umma Hafsa

ABSTRACT

Inhibition of Alpha-amylase, enzyme that plays a role in digestion of starch and glycogen, is considered a strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity, Plants are an important source of chemical constituents with potential for inhibition of Alpha-amylase and can be used as therapeutic or functional food sources. Uvaria littoralis, belonging to the family Rutaceae is a tree and is widely distributed all over the Bangladesh. it, is has been used in traditional medicine for the treatment of diabetic mellitus. In the present study, methanolic extracts of Uvaria littoralis which are used in the Ayurvedic traditional system of medicine to treat diabetes were tested for their inhibitory effect on α-amylase. The results revealed that crude methanol extracts (20.6 ±25.52) of Uvaria littoralis with four fraction pet-ether fraction, (20.67 ± 25.47), chloroform fraction (6.84 ± 0.59), Ethyl acetate fraction (6.02 ± 1.11), methanol+water fraction (5.77 ± 1.14). Among all fraction methanol+water exhibited significant reduction in amylase activity but less than acarbose (standarded 5.7 ± 0.24). In cytotoxicity test among the extractives of U.litoralis the most potent activity was found in Methanol+water fraction (MWF) and the ED50 value of MWF was 72.72mg/ml. Membrane stabilization is the method through which local anesthetics work. This membrane stabilization is done by hypotonic solution induced method. In hypotonic solution induced conditions, the extract of Uveria littoralis were found to inhibit lysis of erythrocyte membrane within the range of 90.75±7.25% to 99.20±0.60%. Me+Water extract of Uveria Litorolious displayed high inhibition (99.20±0.60%) hemolysis of RBC as compared to 96.58±3.56 demonstrated by acetyl salicylic acid.

Keywords: Alpha-amylase, cytotoxicity, membrane stabilizing activity, conclusion.


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