European Journal of Biomedical and Pharmaceutical Sciences

HYPOALBUMINEMIA ON ADMISSION IS ASSOCIATED WITH INCREASED MORTALITY IN HOSPITALIZED PATIENTS PRESENTING WITH SEPSIS

Dr. Ahmed Farhan*, Dr. Uzma Mumtaz, Dr. Aneza Jalil, Dr. Muneeb Ali and Dr. Muzaffar Shoaib

ABSTRACT

Background: Hypoalbuminemia has been associated with worse clinical outcomes in a variety of conditions including kidney diseases, heart failure, trauma patients and sepsis. This study was carried out to evaluate admission hypoalbuminemia as a predictor of mortality in patients hospitalized with sepsis. Methods: All patients admitted with sepsis were enrolled in the study after the inclusion and exclusion criteria were met. Admission and serial albumin levels were done in all patients. Patients were followed and outcomes were measured in terms of patients either discharged or dying during hospital stay. Results: A total of 110 patients were enrolled in the study with a mean age of 42 years and a slight male predominance (53.6%). Baseline serum albumin was below the reference range in most of our patients with a mean serum albumin of 3.06 mg/dl. Hypoalbuminemia was associated with a prolonged hospital stay. Patients who died had a mean serum albumin levels significantly lower than those who were discharged.

Keywords: hypoalbuminemia, sepsis, mortality.