Abstract
SYNTHESIS OF SOME SUBSTITUTED IMINES CONTAINING TRIFLUOROMETHYL PYRIDINE AND EVALUATION OF ITS BIOLOGICAL ACTIVITY

Kaushik Narbherambhai Patel*, Jayesh Jivanlal Modha, Hardik Ashokbhai Mehta

ABSTRACT

Pyridine moiety shows high anti-bacterial activity, so to synthesis newer pyridine containing imine derivatives 2-fluoro-6- (trifluoromethyl)pyridine and 4-hydroxymethylbenzoate were reacted in DMF to get pyridine moiety having ether linkage, which was further treated with hydrazine to get benzohydrazide, which on reaction with different substituted acetophenones to get different imines containing trifluoromethylpyridine. Reaction progress were checked by TLC method and Characterization was done by different spectroscopic method. On microbial screening against gram +ve and gram –ve bacteria and fungal strain. Many of them shows significant activity.

Keywords: Trifluoromethylpyridine, imine, Pyridine, hydrazine, acetophenone, ether.


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