Abstract
COMPARATIVE STUDY OF EGATLOV MEASUREMENT IN ISOLATED ADIPOCYTES CELLS FROM OBESE TYPE TWO DIABETIC PATIENTS AND HEALTHY CONTROLS

Hasan F.Al-azzawie*, Nabaa S.Ibadi and Mohammed F.Al-Kotobe

ABSTRACT

Obesity is associated with several chronic conditions such as atherosclerosis and hypertension. All of these are risk factors that contribute to metabolic syndrome, which in turn can lead to cardiovascular disease and type 2 diabetes. In this study, we aimed to measure the voltage of adipocyte cell membrane and to show the relationship between its measurements with insulin resistance and serum levels of adiponectin, an anti-inflammatory adipokines, in obese type 2 diabetes compared with non diabetic obese subject. Serum concentrations of adiponectin, insulin, and glucose were measured in 50 obese men (BMI > 29) with type 2 diabetes, aged 37 to 53 years and having a body weight of 80 to 100 kg. Insulin resistance index values were calculated using measurements of fasting glucose and insulin levels. Using Pearson’s correlation test, the relationship of serum adiponectin concentration with insulin resistance, serum glucose, and insulin levels, was determined.The results showed a significant inverse relationship between adiponectin concentration and insulin resistance in type 2 diabetic patients (p = 0.000, r = -0.59). In addition, a significant relationship was observed between fasting glucose and adiponectin levels (p = 0.005). The relationship between insulin and adiponectin levels was not significant (p = 0.196). Our findings indicate that the concentration of adiponectin, an anti-inflammatory and antidiabetic marker, is a precise insulin resistance predictor in obese patients with type 2 diabetes.There was a significant difference in voltage value of adipocyte cell membrane isolated from diabetic patients (-34.05mv) compared with (-61.140 mv) in healthy group and these value negatively correlated with insulin levels(r= - 0.67,P<0.001).

Keywords: Adipocyte, T2DM, Intracellular recording.


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