Abstract
FORMULATION AND EVALUATION OF QUINAPRIL HCL FLOATING TABLET

Vempati Poornodai, K. Srinivasu, Manju Thomas and *Vulli Venkata Rao

ABSTRACT

Quinapril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension and congestive heart failure. A prodrug, it is converted to its active metabolite, quinaprilat, in the liver. Quinapril HCl is classified in the Biopharmaceutics Classification Scheme as a class I drug, it has a high solubility and high permeability but the rate limiting step is gastric emptying time. The main objective of this study is to formulate the quinapril floating tablets to float in stomach over the drug release. The present study concludes that gastro retentive floating tablets of Quinapril prepared using HPMC K 4 M, HPMC K 15 M and HPMC K 100 M as retarding polymers. Among all the formulations, F5 formulation has shown optimised results. Present study concludes that gastro retentive floating system may be a suitable method for Quinapril.

Keywords: Quinapril, Prodrug, Floating system, HPMC.


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