European Journal of Biomedical and Pharmaceutical Sciences

VISCOSITIES OF L - PROLINE AND L- THREONINE IN (0.05, 0.10, 0.15, AND 0.20) MOL·KG?1 AQUEOUS METFORMIN HYDROCHLORIDE SOLUTIONS AT DIFFERENT TEMPERATURES

Rajagopal K., Shailajha S., Mohamed Roshan M.* and Roy Richi Renold G.

ABSTRACT

viscosity (η) measurements of amino acids L-Proline and L-Threonine in aqueous solutions of metformin hydrochloride (an antidiabetic drug) (0.05, 0.10, 0.15 and 0.20 mol·kg−1) have been carried out in the concentration range (0.025−0.15 mol·kg−1) at 298.15, 303.15, 308.15, 313.15 and 318.15 K. Viscosity B-coefficients of Jones-Dole equation, B- coefficients transfer (ΔB), temperature dependent of B- coefficient, free energy of activation per mole of solvent (Δμ10*) and solute (Δμ20*) are estimated using viscosity data. Our study concludes the existence of strong solute solvent interaction in the studied systems. Furthermore, structure making and breaking behaviour of both amino acids have also been assessed in aqueous metformin hydrochloride solutions. The thermodynamics of viscous flow has also been discussed.

Keywords: L-proline, L-threonine, Metformin Hydrochloride, B- coefficients, Free energy of activation per mole of solvent (??10*) and solute (??20*).