EVALUATION OF ANTIDIABETIC AND HYPOLIPIDEMIC ACTIVITY OF CLERODENDRUM INFORTUNATUM LINN. IN ALBINO RATS
Suman Kumar Mekap*, Rabi Narayan Rana, Manoj Panigrahy, Deepak Kumar Sarangi, Suraj Sahoo, Jyotirmaya Sahoo
ABSTRACT
Background: Diabetes mellitus is a chronic metabolic disorder of carbohydrate, lipid, and protein metabolism. It is characterized by hyperglycemia, glycosurea, hyperlipidemia and negative nitrogen balance, due to insufficient or complete cessation of insulin synthesis, or secretion and/or peripheral resistance to insulin action. Diabetes has been known to medical sciences longer than any other hereditary metabolic disorder. Clerodendrum infortunatum family: Verbenaceae is commonly known as Bhant in Hindi, has been traditionally used in the Siddha system of medicine as a chief ingredient of many polyherbal formulations for the treatment of various ailments. However, no scientific evidence is available to validate the folklore claim. Objective: The present study has been designed to evaluate the antidiabetic and hypolipidemic activity of Clerodendrum infortunatum. Materials and methods: The antihyperglycaemic activity was evaluated in normal, glucose-loaded and Streptozotocin-induced hyperglycaemic rats (single and multi dose treatment). Results: In normoglycaemic rats, the test extracts showed progressive fall of blood glucose level till the end of 8 h. In glucose loaded animals (OGTT), reduction in blood glucose level was observed after 60 minutes of administration of the test substances. The maximum reduction was observed at 4 h with Methanol: Dichloro methane extract exhibiting maximum improvement in glucose tolerance. Continuous administration of extracts or 14 days leads to significant decrease in serum total cholesterol, triglycerides, LDL and VLDL levels, while increase in total protein and HDL levels was recorded. Conclusion: The present study demonstrated that the leaves of C. infortunatum had remarkable preclinical anti-hyperglycemic activity in STZ-induced diabetic rats. Our results contribute towards validation of the traditional use of C. infortunatum in the treatment of diabetes.
Keywords: Anti-hyperglycemic, hypolipidemic, C. infortunatum, Streptozotocin, Glibenclamide.
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