European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION DEVELOPMENT AND EVALUATION OF ETORICOXIB ORAL DISINTEGRATION TABLET

S. R. Senthilkumar*, N. Venkatesan, R. Ramprasad, Nilsha Anil, J. Amutha Iswarya Devi and R. Subish

ABSTRACT

Etoricoxib has some of the ideal characteristics required for an orally disintegrating tablet.[1,2,3] There were some challenges faced during this formulation development. The aims of the present research were to mask the bitter taste of etoricoxib and to formulate orally disintegrating tablets of taste masked drug.[4] Taste masking was performed by ion resin complexation etoricoxib with suitableresin indone 294.[5] Disintegration time was effectively reduced by adding disintegrating agents such as crospovidone and croscarmellose sodium.[6] The increasing the concentration of tartaric acid the ph level was change and it also reduced the bitter teats.[7] The resultant ODT tablets were then evaluated for particle size and in vitro taste masking. The tablets prepared were evaluated for weight variation, thickness, hardness, friability, drug content, water content, in vitro disintegration time and in vitro drug release of etoricoxib.[8]

Keywords: Etoricoxib has some etoricoxib with suitableresin indone etoricoxib.