Abstract
A COMPARATIVE IN VITRO CYTOTOXICITY STUDY OF COLLOIDAL SILVER AND CHITOSAN STABILIZED SILVER NANOPARTICLES ON MCF-7 AND HEPG2

P.Prema* and S.Thangapandiyan

ABSTRACT

Recently nanotechnology research was discussed for the generation of nanoparticles as anticancerous agents. It is mandatory to elaborate the application of colloidal silver and chitosan stabilized silver nanoparticles in general and anticancerous property in particular. The present study was aimed to investigate the in vitro cytotoxicity effect of colloidal silver and chitosan stabilized silver nanoparticles against human breast cancer cells (MCF-7) and liver cancer cells (HepG2) towards the development of anticancer drugs. The colloidal silver and chitosan stabilized silver nanoparticles were fabricated by using sodium borohydride as novel reducing agent. It was well characterized by UV, SEM, EDS, XRD, and AFM studies showed spherical shaped nanoparticles in the size range of 20-40nm and in slightly agglomerated form. Surprisingly it also showed cytotoxic effect against MCF-7 and HepG2 cell lines were confirmed by MTT and cell viability assays. There was an immediate induction of cellular damage in terms of loss of cell membrane integrity, oxidative stress and apoptosis were found in the cell which treated with colloidal silver and chitosan stabilized AgNPs. This may be a first report on anti- MCF-7 and anti-HepG2 property of colloidal silver and chitosan stabilized AgNPs in the fourth generation of nanoparticle research. It is necessary to study the formulation and clinical trials to establish the nano drug to treat cancer cells.

Keywords: colloidal silver, chitosan stabilized AgNPs, MCF-7 and HepG2.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MAY ISSUE PUBLISHED

    MAY 2024 Issue has been successfully launched on 1 MAY 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT