European Journal of Biomedical and Pharmaceutical Sciences

MULTICENTRE TRIAL TO ASSESS THE EFFICACY OF OCTREOTIDE IN THE MANAGEMENT OF ACUTE PANCREATITIS

Mayuri Khobragade Kamble, Ashok Tarachand Kamble and Dr. Pratik Abhishek*

ABSTRACT

Introduction: Acute pancreatitis is an inflammation and autodigestion of parenchyma of pancreas which lead to injury or destruction of acinar components. It can be initiated by factors, like gallstones, alcohol, trauma, and infections, etc. The mortality and morbidity of mild acute pancreatitis is low but patients with severe acute pancreatitis commonly develop complications and have a mortality of 10-50%, inspite of all available treatment strategies. Octreotide is a synthetic, a long acting octapeptide analogue of the native hormone somatostatin, became available in 1982. It is a powerful inhibitor of basal and stimulated exocrine pancreatic secretion in healthy volunteers and can be given subcutaneously. Octreotide have been shown to inhibit both pancreatic endocrine and exocrine function. This study has been conducted to study the etiology of acute pancreatitis and to see the role of octreotide in management of acute pancreatitis. Materials and methods: This is a prospective study consisting of two groups of 25 patients each. One group was treated with octreotide whereas the other group was treated without injection octreotide. Both the groups received antibiotics, analgesics, fluid support in addition. Response was assessed on the sequential assessment of serum amylase, serum lipase and abdominal ultrasound. Results: Results were analysed in view of age distribution, gender distribution, clinical features, etiology, biochemical response and radiological response. Statistical software was used to see the statistical significance in comparision. Discussion: Results of the present study was compared with the existing literature on acute pancreatitis, etiological factors and role of octreotide. Conclusion: This study was undertaken to see the etiology of acute pancreatitis and the effect of subcutaneous octreotide on the serum levels of amylase and lipase in patients with acute pancreatitis. The idea was to see if octreotide can significantly reduce the high levels of serum amylase and lipase in patients with acute pancreatitis. Subcutaneous octreotide reduced the levels of both the enzymes in all cases. So it can be stated that subcutaneous injection of octreotide can be used in the management strategy of acute pancreatitis. It helps in preventing the enzyme related damage to the pancreas.

Keywords: Acute pancreatitis, serum amylase, serum lipase, octreotide.