ERECTILE DYSFUNCTION IN DIABETES AND ROLE OF DELPHINIUM DENUDATUM WALL
Dr. Zaffar Hussain*
ABSTRACT
Erectile dysfunction is the persistent inability to achieve or sustain a penile erection of adequate rigidity to make intercourse possible or satisfactory. Diabetes mellitus is the most common organic cause for erectile dysfunction, the onset of which starts about 15 years earlier in the diabetic than in the non-diabetic population. Erectile dysfunction increases with age and presence of vascular co morbidities. Approximately present in 7% in the 2nd, 18% in the 5th, 25% in the 6th and 80% in the 8th decades. Nitric oxide (NO) is the major chemical mediator resulting in relaxation of smooth muscle cells in the erectile tissue, thus allowing the erection to occur. Nitric oxide release results in the release of cyclic GMP (cGMP), which is broken down by PDE-5. The PDE-5 inhibitors prevent breakdown of cGMP thereby enhancing erection under situations of normal sexual stimulation. The importance of a thorough history and clinical examination along with an understanding approach, and a serious attempt to stabilize blood sugar levels cannot be overemphasized, Clinical history should include time course (sudden onset may correlate with reversible cause such as medication, psychosocial stress, psychiatric complaint), cause (psychogenic vs. organic), and change in libido. Delphinium denudatum has been established to be safe and effective in the management of erectile dysfunction, reduces the oxidative stress in the nerves by the regulation of redox signalling and inhibiting the excess reactive oxygen species (ROS).
Keywords: Erectile Dysfunction, Diabetes Mellitus, Delphinium Denudatum Wall.
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