EVALUATION OF ANTI-PROLIFERATIVE EFFECT OF A SEAWEED CALLED “PADINA PAVONICA” (LINNAEUS THIVY N.D. ) FROM THE LEBANESE COAST AGAINST JURKAT CANCER CELL LINE
Mona Y. Tannoury*, Saad G. Saba, Antoine M. Saab, Akram Hijazi and Mona Diab-Assaf
ABSTRACT
Most researches in the field of cancer nowadays, have the purpose of finding a drug with a selective cytotoxicity to kill the cancer cells with fewer side effects than those of the current therapies. Among all the marine organisms, brown seaweeds seem to have a potent anti-cancer effect against many cancer cell lines. In our paper, we assessed the cytotoxic activity of three crude extracts of brown algae named Padina pavonica (Linnaeus) Thivy, n.d. collected from the Lebanese coast, on Jurkat human cancer cell line by using the trypan blue exclusion assay. After 72h of treatment, all the extracts prepared from P. pavonica were cytotoxic on Jurkat cancer cells: the aqueous extract with IC50 values of 21.78 μg/mL, methanol: water extract with IC50 values of 31.1μg/mL, and the n-hexane extract with IC50 values of 40 μg/mL. More researches concerning the identity of the cytotoxic compounds in the crude extracts are crucial to identify new and efficient anti-cancer drugs.
Keywords: brown algae; Padina pavonica; cytotoxic activity; Jurkat cell line; trypan blue exclusion assay.
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