European Journal of Biomedical and Pharmaceutical Sciences

RECENT ADVANCES IN THE DEVELOPMENT OF NANOPARTICLES FORMULATIONS FOR THE TREATMENT OF MALARIA

Sahil Kumar*, Kulvinder Singh, Divya Arora, Kumari Shilpa Sharma and T. R. Bhardwaj

ABSTRACT

The present review highlights the advancement in nanoparticles formulations for the treatment of malaria. An attempt has been made to describe various novel drug delivery systems based on approaches such as polymeric, metallic, natural, chitosan/antisense (AS) and chitosan/sense (S) oligodeoxynucleotide based nanoparticles etc. for the treatment of malaria. The polymer such as chitosan, hydroxyl propyl methyl cellulose and polyvinyl pyrrolidone; the metals like gold and silver and other carriers such as glyceryl-dilaurate, albumin etc. have been explored for the development of novel nanoparticles formulations. These developed nanoparticles formulations have improved the targeted drug delivery of various clinically used antimalarial therapeutic agents such as hydroxychloroquine, curcumin, artemisinin, artemether and and lumefantrine etc.

Keywords: nanoparticles, polymers, malaria, chitosan, gold nanoparticles, silver nanoparticles.