European Journal of Biomedical and Pharmaceutical Sciences

PSORIASIS: A CURRENT UPDATED REVIEW

*Asra Jabeen, Dr. S. Rani, Dr. Mohammed Ibrahim and Abdul Saleem Mohammad

ABSTRACT

Psoriasis, a chronic inflammatory skin disease affecting about 2-3% of the world wide population, is characterized by hyperproliferation and abnormal differentiation of keratinocytes. Psoriasis is an immune mediated inflammatory disease, which is having no permanent cure. Though, there are several treatment methods to treat psoriasis, no particular medication claims a satisfactory and complete remedy. A wide range of synthetic therapeutic agents have also been reported to cause psoriasis as their adverse effect. Herbal drugs by virtue of their safe nature and easy availability may lend themselves as potential anti-psoriatic moieties. Before developing a herbal drug candidate the key players of psoriasis to develop should be thoroughly understood, which includes T-cell activation, T-cell trafficking, Cytokinase inhibition.

Keywords: Psoriasis, inflammation, hyperproliferation, keratinocytes, cytokinase.