European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF OXIDATIVE STRESS MARKERS IN IRAQI PATIENT WITH MAJOR BETA THALASSEMIA

Hasan F. Al-Azzawie* and Ali T. Kamil

ABSTRACT

The antioxidant status and oxidative damage to children with Iraqi β- thalassemic major children were evaluated. Samples from 80 children with β-thalassemic major and 40 healthy controls were used. All children were under 13 years of age. Our results showed that plasma thiobarbituric acid reactive substances (TBARS) were elevated in β- thalassemic children compared to controls together with compensatory increase in superoxide dismutase (SOD), glutathione peroxidase(GPx)activities and decrease in catalase (CAT) activity, reduced glutathione(GSH),Vitamine E and C. Elevated serum ferritin showed positive correlation with elevated liver enzyme levels except gamma glutamyl transferase (GGT), confirming liver involvement due to iron overload. Serum ferritin also showed a positive correlation with elevated TBARS and SOD, suggesting that iron overload is involved in the oxidative stress shown in cells.

Keywords: Enzymatic and non enzymatic antioxidant, thalassemic, ferritin.