European Journal of Biomedical and Pharmaceutical Sciences

SEPARATION OF THE ENANTIOMERS IBUPROFEN USING AMINO ACIDS BY TLC

Zohra Chakrar, Zerkout Said*, Berkoune Hayet, Chihab Houda, Rachid Fegas

ABSTRACT

The enantiomeric separation of racemic compounds of ibuprofen, was performed by thin-layer chromatography on silica gel plates impregnated with optically pure amino acids, as the chiral selector and by using different amino acids in acetonitrile-methanol-water as the solvent system as chiral selector. This is in order to determine the best experimental conditions that enable us to separate the enantiomer’s ibuprofen: mobile phase, stationary phase and the best amino acid as a chiral selector.

Keywords: énantiomers , énantiomeric séparation , racemic compounds , ibuprofen, thin- layer chromatography , amino acid , chiral selector.