Abstract
THE ROLE OF ALDH2 AND ADH1B POLYMORPHISM IN ALCOHOL DEPENDENCE: A CASE- CONTROL STUDY FROM BILASPUR, CHHATTISGARH, INDIA

Arjun Rao*, Akhilesh Tiwari, Moumita Sinha, Sujit Nayak, Sudhanshu Bhatt and Bharti Ahirwar

ABSTRACT

Polymorphism at the functional region of the gene encoding Alcohol Dehydrogenase (ADH) 1B and Aldehyde Dehydrogenase (ALDH2) are viewed as most essential among a few hereditary factors causing complex disorder - Alcohol Dependence. From population of India, there is insufficient account of data on commonly studied Arg47His and Glu487Lys polymorphisms from Alcohol Dependent subjects. In this article, we report for the first time, allelic and genotypic frequencies of Arg47His and Glu487Lys single nucleotide polymorphisms (SNPs) in Chhattisgarh population (Central India). A sum of 50 Alcohol Dependent Cases, satisfying DSM IV criteria and 50 age sex matched controls were genotyped utilizing the Polymerase Chain Reaction– Restriction Fragment Length Polymorphism technique. The feature of the examination findings was the interestingly high frequency of the ALDH2*2/*2 genotype (among Alcohol Dependent Cases) being a risk genotype for Alcohol Dependence.

Keywords: Alcohol dependence, alcohol dehydrogenase, aldehyde dehydrogenase, genotype, allele frequency.


[Full Text Article]   [Download Certificate]

Indexing

Indexing

Best Article Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) is giving Best Article Award in every Issue for Best Article and Issue Certificate of Appreciation to the Authors to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: JULY ISSUE PUBLISHED

    JULY 2026 Issue has been successfully launched on 1 JULY 2026.

  • EJBPS: New Impact Factor 2026

    EJBPS Impact Factor has been Increased from  7.482 to 8.181 for Year 2026.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     
Google Scholar Index Copernicus Indian Science Publications Urlich's Periodicals Directory, Proquest, UK (In Process) Research Bible, Fuchu, Tokyo. JAPAN UDLedge Science Citation Index International Society for Research activity (ISRA) Scientific Indexing Services (SIS) InfoBase Index (In Process) SJIF Impact Factor Scholar Article Impact Factor, SAIF Universal Impact Factor CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Global Impact Factor (GIF) (0.377) IP Indexing (IP Value 3.77) Web of Science Group (Under Process) Directory of Research Journals Indexing Scope Database Academia Academia Doi-Digital Online Identifier Doi-Digital Online Identifier ISSN National Centre Zenodo Indexing International CODEN Service, USA

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT