Abstract
THE ROLE OF ALDH2 AND ADH1B POLYMORPHISM IN ALCOHOL DEPENDENCE: A CASE- CONTROL STUDY FROM BILASPUR, CHHATTISGARH, INDIA

Arjun Rao*, Akhilesh Tiwari, Moumita Sinha, Sujit Nayak, Sudhanshu Bhatt and Bharti Ahirwar

ABSTRACT

Polymorphism at the functional region of the gene encoding Alcohol Dehydrogenase (ADH) 1B and Aldehyde Dehydrogenase (ALDH2) are viewed as most essential among a few hereditary factors causing complex disorder - Alcohol Dependence. From population of India, there is insufficient account of data on commonly studied Arg47His and Glu487Lys polymorphisms from Alcohol Dependent subjects. In this article, we report for the first time, allelic and genotypic frequencies of Arg47His and Glu487Lys single nucleotide polymorphisms (SNPs) in Chhattisgarh population (Central India). A sum of 50 Alcohol Dependent Cases, satisfying DSM IV criteria and 50 age sex matched controls were genotyped utilizing the Polymerase Chain Reaction– Restriction Fragment Length Polymorphism technique. The feature of the examination findings was the interestingly high frequency of the ALDH2*2/*2 genotype (among Alcohol Dependent Cases) being a risk genotype for Alcohol Dependence.

Keywords: Alcohol dependence, alcohol dehydrogenase, aldehyde dehydrogenase, genotype, allele frequency.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: JUNE ISSUE PUBLISHED

    JUNE 2023 Issue has been successfully launched on 1 JUNE 2023.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT