Abstract
A REVIEW ON OXAZOLONE, IT’ S METHOD OF SYNTHESIS AND BIOLOGICAL ACTIVITY

Niraj Sharma, Janmajoy Banerjee*, Nomi Shrestha and Deepak Chaudhury

ABSTRACT

Oxazolones are five membered heterocyclic entity containing oxygen and Nitrogen. It is important synthons for the synthesis of various biologically active compounds and is an important pharmcophore of synthesized drugs. Oxazolone is being synthesized in many ways since 1883. It shows marked pharmacological activity such as: antimicrobial, anifungal, anti-diabetic, anti-cancer, and anti-inflammatory. In present article we review the mechanism of oxazolone formation, it’s chemistry, diversity oriented synthesis of oxazolone, various method of synthesis and pharmacological activity of synthesized compound along with SAR.

Keywords: Erlenmeyer-Plochl reaction, Friedel–Crafts reaction, Contact allergen, anti-angiogenic.


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