European Journal of Biomedical and Pharmaceutical Sciences

PHARMACOLOGICAL SCREENING OF ANTIDEPRESSANT ACTIVITY OF PLANT TRICHOLEPIS GLABERRIMA

G. Kiranmai*, I. Veena Rani and Afreen Sulthana

ABSTRACT

Tricholepis glaberrima (Asteraceae), popularly known as “Brahmdandi” has been used for the treatment of variety of disease. The main objective of this research work was to evaluate the antidepressant activity of Tricholepis glaberrima in rats. The study was undertaken to evaluate the possible antidepressant effect of Tricholepis glaberrima aerial parts using forced swimming test and tail suspension test models of depression. Imipramine has been taken as a standard drug with a dose of 10mg/kg, Group-1(untreated), group-2 (standard) received imipramine orally. Group 3, 4 and 5 received METG at the doses of 200, 400 and 600mg/kg respectively. Methanolic extract of aerial parts of Tricholepis glaberrima produced significant antidepressant like effect at the dose of 600mg/kg in both models of FST and TST which indicated reduction in immobility time. The efficacy of METG at 600mg/kg found to be comparable to that of standard drug Imipramine at 10mg/kg. The results of present study indicated that methanolic extract of aerial parts of Tricholepis glaberrima possesses significant antidepressant activity compared to that of standard drug imipramine.

Keywords: Tricholepis glaberrima, Forced swimming test, Tail suspension test, Methanolic extract of Tricholepis glaberrima, Imipramine.