European Journal of Biomedical and Pharmaceutical Sciences

ACUTE ORAL TOXICITY STUDY OF CHANDRAKANTHI CHOORANAM

B. Akila*, K. Manickavasakam and T. Kavitha

ABSTRACT

Chandrakanthi Chooranam (CKC) is a classical preparation which consists of twenty five ingredients and is indicated for the treatment of oligozoospermia, vaginal diseases, veneral diseases, polyuria and in all biliousness. The present study was aimed to conduct acute oral toxicity study in wistar albino rats and to establish the safety of the CKC and this article presents the results of 14 days acute oral toxicity study. Acute oral toxicity study was carried out following the World Health Organization (WHO) guidelines 2000. The therapeutic dose of CKC is 12 gm/day. For acute oral toxicity study for CKC the higher dose selected was 10 times the therapeutic dose (10.8 gm/kg b.wt of rat; as single dose) to the rats. On necropsy, no gross pathological abnormalities were observed in the vital organs of the rats.

Keywords: Chandrakanthi chooranam, WHO guidelines, acute toxicity, oligozoospermia, sastric preparation.