Abstract
DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROSCOPY METHOD FOR ESTIMATION OF PALIPERIDONE HCL

Imran Tadwee*, Pravin Bhalerao, Pavankumar Ade, Arshiya Khan and Dr. Sadhana Shahi

ABSTRACT

Paliperidone is an atypical antipsychotic drug .paliperidone is a selective dopamine type 2(D2) and serotonin type 2 (SHT2A) receptor antagonisms, developed for the treatment of schizophrenia. To develop and validate simple, accurate, rapid, precise, reproducible and cost effective spectrophotometric method for the quantitative estimation of paliperidone HCl in a pharmaceutical formulation. The developed UV spectrophotometric method for the quantitative estimation of paliperidone HCl is based on measurement of absorption maximum wavelength 236 nm using paliperidone HCl as a solvent. The stock solution of paliperidone HCl was prepared, and subsequent suitable dilution was prepared in distilled water to obtained standard curve. The standard solution of paliperidone HCl shows absorption maxima at 236.nm.

Keywords: Paliperidone, UV spectroscopy, method development.


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