FORMULATION AND EVALUATION OF BIOPOLYMERS COATED PELLETS OF CYCLOPHOSPHAMIDE FOR COLON DRUG DELIVERY
Madhu Gudipati* and Ramarao Nadendla
ABSTRACT
The present study objective was to develop novel colon specific drug delivery systems for cyclophospahmide using konjac glucomannan as a biodegradable polymeric carrier and to coat the optimized batches with a pH dependent polymeric coating solution containing zein. Pellets containing four proportions of KGM and zein were prepared. The pellets were evaluated for physicochemical properties, drug content, dissolution, water uptake & erosion characteristics, in-vitro drug release studies. The amount of cyclophospahmide released from the biopolymers coated pellets at different time intervals was estimated by UV spectrophotometric method at 260nm. Zein coated KGM pellets prevented release of the cyclophospahmide in the physiological environment of stomach and small intestine depending on the proportion of biopolymers used in the formulation. The dissolution profile and in vitro release kinetics showed that pectin pellets were promising for colon delivery of the drug. The findings of the present study conclusively state that biopolymers coated pellets are promising for colon delivery of cyclophospahmide to synchronize the chronobiological symptoms for effective treatment of colon cancer.
Keywords: Cyclophospahmide, Konjac Glucomannan, Pellets, Zein, Colon Drug Delivery.
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