European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF ETHANOLIC EXTRACT OF MIRABILIS JALAPA ROOTS AGAINST PARACETAMOL INDUCED HEPATOTOXICITY

Satla Anusha* and Syeda Nishat Fathima

ABSTRACT

The present study was carried out to evaluate the effect of ethanolic extract of Mirabilis Jalapa roots against Paracetamol (2.0 g/kg body weight, orally) induced hepatotoxicity. Various biochemical parameters and histopathological profile of liver tissue were considered to evaluate the hepatoprotective activity of ethanolic extract. In serum total bilirubin, total protein, aspartate transaminase, alanine transaminase and alkaline phosphatase were determined to assess the effect of the extract on the Paracetamol induced hepatic damage. Results of this study revealed that the serum markers in the animals treated with Paracetamol were significantly increased indicating severe hepatic damage by Paracetamol, whereas the blood samples from the animals treated with ethanolic extract of Mirabilis Jalapa roots(250mg/kg body weight, orally) showed significant reduction in the serum markers indicating the effect of the plant extract in restoring the normal functional ability of the hepatocytes. The present study reveals that the ethanolic extract of Mirabilis Jalapa roots could afford a significant protection against paracetamol‐induced hepatocellular injury.

Keywords: Mirabilis Jalapa roots, Paracetamol, Hepatoprotective activity.