European Journal of Biomedical and Pharmaceutical Sciences

CORRELATION BETWEEN TREATMENT OF RHEUMATOID ARTHRITIS USING NON BIOLOGICAL DMARDS AND DISEASE ACTIVITY USING RAPID-3 SCALE

Dr. Chitrak Bansal*, Dr. Prithpal Singh Matreja and Dr. Najmul Huda

ABSTRACT

Rheumatoid Arthritis (RA) is a chronic inflammatory autoimmune disorder which results in destruction of joints with increased morbidity and mortality. Due to requirement of prolonged therapy it is need of hour to evaluate the correlation between RAPID-3 (Routine Assessment of Patient Index Data 3) and disease activity among patients treated for RA using non-biological disease modifying anti rheumatoid drugs. Hence this randomized cross sectional study was planned to done among patients attending Orthopaedic OPD, found suitable after applying inclusion and exclusion criteria. Patients were divided into 5 groups on the basis of drugs prescribed to them. Group A was prescribed with Methotrexate, Hydrxychloroquine, Deflazacort and Piroxicam. Group B was prescribed with Methotrexate, Salfasalazine, Deflazacort and Piroxicam. Group C was prescribed with Methotrexate, Hydroxychloroquine and Piroxicam. Group D was prescribed with Methotrexate Salfasalazine and Aceclofenac and Group E was prescribed with Methotrexate, Hydroxychloroquine and Aceclofenac. RAPID-3 score of patients at day 0 and after 60 days of treatment were noted and evaluation was done for correlation and efficacy of treatment. In our study this was observed that (n=08) patients of Group A had shown the most efficacy towards treatment of RA which was reflected by significant decrease in mean RAPID-3 score of these patients after 60 days of treatment. Our study indicates that RAPID-3 scoring system can used as a reliable tool for quick assessment of disease activity and efficacy of treatment in a busy clinical environment.

Keywords: Rheumatoid Arthritis, RAPID-3, Disease Modifying Anti-Rheumatoid Drugs.