PREPARATION AND CHARACTERIZATION OF VALSARTAN LOADED SOLID LIPID NANOPARTICLES
Milind P. Wagh*, Nikhil N. Kadam, Rohit R. Patil and Dhananjay M. Patwardhan
ABSTRACT
Nanotechnology is recognized as a landmark innovation and is considered “the sixth truly revolutionary technology introduced in the modern world”. Nanotechnology has been widely explored in Anticancer Drug Therapy, Immunology, Antitubercular therapy, Cardiovascular Drug Delivery etc. While dealing with different categories of cardiovascular drugs the main obstacles in oral delivery is their low bioavailability. So here an attempt was made to formulate Solid lipid nanoparticles of Valsartan using high shear homogenization coupled with ultrasonication technique. Valsartan is a new potent, highly selective and orally active having low solubility, low bioavailability. The method was optimized by applying 32 level factorial design. The effects of composition of lipid materials and surfactant on particle size, drug entrapment efficiency and in vitro drug release behavior were investigated. The mean particles size, Polydispersity index (PDI) and entrapment efficiency of optimized formulation (V-10) was found to be 206.89 nm, 0.53, 80.46% respectively. The drug release study from the nanoformulation was studied in Phosphate buffer 6.8 for the optimized formulation (V-10). The results demonstrated that V-SLN formulation (V-10) showed biphasic behaviour with an initial burst release followed by a sustained release maximum up to 72-79% till 24 hours. The release curve was found to follow Korsmeyer Peppas model (R2=0.98).
Keywords: Valsartan, Solid Lipid Nanoparticles, Homogenization, PDI, Encapsulation efficiency.
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