A COMPARATIVE STUDY ON ANTI DIABETIC ACTIVITY OF CRUDE EXTRACTS OF ENDOPHYTIC FUNGI FROM SEA WEED GRACILARIA CORTICATA
R. Anusha* and R. Ushasri*
ABSTRACT
Diabetes, often referred to by doctors as diabetes mellitus, describes a group of metabolic diseases in which the person has high blood glucose (blood sugar).Insulin is a hormone that is produced by the pancreas. Inhibition of α-amylase, enzyme that plays a role in digestion of starch and glycogen, is considered a strategy for the treatment of disorders in carbohydrate uptake, such as diabetes. Gracilaria corticata have been used since ancient times as food, fodder, and fertiliser and as source of médicine. Gracilaria corticata. Endophytic fungi are one of the potential natural resources for new ant diabetic compound sources. The aim of the study was to compare anti diabetic activity of crude extracts of Endophytic fungi from Gracilaria corticata against diabetes. Endophytic fungi were isolated from seaweed Gracilaria coricata, characterized and identified based on morphological and biochemical characters. The identified endophytic fungi were tested for invitro antidiabetic activity by alpha amylase inhibition assay, method the higehest percentage of alpha amylase inhibition at the concentration of 500μl of ethanolic extract of A. niger that showed 41.4% followed by penicillium (39%) A.fumigatus (33.4%) Phoma spp (28.9%) and Syncephalastrum racemosum (23.7%) in comparison with acetone crude extracts of Penicillium (25.2%), Phoma spp (24.2%), A.fumigatus (21.3%), Syncephalastrum racemosum (19.4%), A.niger (17.4%).
Keywords: Endo phytic fungi, DNS, Gracilaria corticata, Diabetes, Alpha amylase.
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