Abstract
HPLC METHOD FOR THE ASSAY DETERMINATION OF LANSOPRAZOLE PELLETS DOSAGE FORMS

T. Srinivasarao*, M. Vasanthalaxmi and G. Naresh Reddy

ABSTRACT

A simple and rapid High performance liquid chromate graphic method was developed for Assay determination of lansoprazole pellets dosage forms with U.V detection. The chromatographic system consisted of a Zodiac ODS 4.6mm×150mm column, an Isocratic mobile phase of 650ml phosphate buffer+350ml acetonitrile. The flow rate is 1ml/minute and effluent is monitored at 286nm.The lansoprazole was eluted at about 5.681 min with no interfering peak from excipients used for preparation of dosage form. The method was linear over the range of 10-150μg/ml lansoprazole.

Keywords: High Performance Liquid Chromate Graphy, ASSAY, Isocratic, no Interfering Peak.


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