CORRELATION OF GLYCOSYLATED HEMOGLOBIN AND BONE MINERAL DENSITY IN PRE AND POST MENOPAUSAL DIABETIC WOMEN
Kavita Bakshi*, Dr. Sabiha Vali and Dr. Sunil Gupta
ABSTRACT
Post-menopausal osteoporosis is a natural phenomenon. Diabetic postmenopausal women are at higher risk for osteoporosis. The study aimed to evaluate the relationship of HbA1c to bone mineral density (BMD) in type 2 diabetic women. 100 premenopausal and 111 postmenopausal women were selected by purposive sampling from Diabetes Care and Research Center, Nagpur. Fasting (FBG) and postprandial blood glucose (PPBG), Glycosylated Hemoglobin (HbA1c) and Bone Mineral Density (BMD) were assessed by standard methods. Mean age of pre and postmenopausal subjects was 46+ 5.64 and 60 + 6.30 respectively. Insignificant differences were observed in the mean FBG (p=0.2130) PPBG (p=0.1881) and HbA1c (p= 0.1230) between the pre and post-menopausal subjects. Mean BMD- T scores showed significant difference (p=0.014) between the two group of subjects. Prevalence of osteopenia (41.44%) and osteoporosis (20%) was observed in premenopausal subjects. A comparatively higher percent were osteopenic (44%) and osteoporotic (30.63%) in the post-menopausal group. BMD T-scores of premenopausal (r= -1.43) and postmenopausal subjects (r= -1.80) differed significantly (p= < 0.0001). Low +ve insignificant relationship was observed between BMD- T scores and FBG in pre (r= 0.006) and post-menopausal subjects(r= 0.106). Low -ve insignificant relationship was observed between BMD- T scores and PPBG in pre (r= -0.149) and post-menopausal subjects(r= - 0.0363). Relationship of HBAIc to BMD-T scores was low -ve (r= -0.107) in premenopausal subjects and low +ve (r=0.0126) in postmenopausal subjects differing insignificantly. An inverse relationship of HbA1c to BMD- T score was prominently observed in pre-menopausal subjects indicative of bone loss in uncontrolled diabetes irrespective of menopause.
Keywords: FBG, PPBG, HBAIc, BMD T-score.
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