European Journal of Biomedical and Pharmaceutical Sciences

ACRYLAMIDE-INDUCED SYNAPTIC DEPRESSION AND NEURONAL DAMAGE IN DEVELOPING CHICK EMBRYONIC BRAIN

Venkataswamy M., Divya B. J., Suman B., Nagalakshmamma V., Chalapathi P. V., Nagaraju C. and Thyaga Raju K.*

ABSTRACT

The neurochemical synaptic transmission is an essential function of the central nervous system and neurotransmitters play a critical role in this process. The present study carried out to investigate the toxic effects of acrylamide in alterations of acetyl cholinesterase (AChE) and various neurotransmitters like Monoamine, epinephrine, nor epinephrine, glutamate and gamma-aminobutyric acid (GABA). After 72h of acrylamide treatment to egg, the tissues were collected from the 11th day (d11) developing chick embryos exposed to different doses (0.2, 0.4, and 0.6mg) of acrylamide toxicity. The present results showed that epinephrine, nor epinephrine, dopamine levels were reduced and increased levels of gamma-aminobutyric acid (GABA) and acetyl cholinesterase (AChE) with increasing doses of acrylamide. These findings concluded that high doses of acrylamide positively associated with neurotoxicity synaptic depression and neuronal damage in a dose-dependent manner.

Keywords: Acryalmide, Acetyl cholinesterase, Chick embryos, Epinephrine, Gamma-aminobutyric acid, neurotransmitter.