Abstract
DESIGN, DEVELOPMENT AND EVALUATION OF ORNIDAZOLE STRIP IN DENTAL INFECTION

Ashish Gorle*, Manoj Patil and Rushikesh Mahajan

ABSTRACT

Several peoples around the world suffer from dental diseases, number of them will get oral therapy and most of the drug shows irritation in GIT and thus absorbs systemically and imparts toxicity. Hence to reduce gastric irritation and systemic toxicity, authors developed the site specific delivery of ornidazole in treatment of periodontitis, drug has an excellent activity against anaerobic microbes. Formulations were prepared by utilizing polymers PEO and gellan gum, and developed by solvent casting technique with the used of plasticizer (PEG-400). Preformulation studies were performed on drug and excipients. Physical characterization of films was done by thickness, folding endurance, weight variation, drug content, percent moisture loss, tensile strength, percent elongation etc. In vitro diffusion, stability and the antibacterial study was also performed on selected formulations. FT-IR and DSC study revealed no interaction found between drug and polymers utilized hence suitable for films. Formulations showed good uniformity of drug, there is no any kind of effect on moisture loss test. Formulations showed high weight & thickness with gellan gum when compared to PEO also possesses good tensile strength. By increasing the concentration of PEO in the formulation rate of release was retarded when compared with gellan gum. Formulation F5 released 94.56% of the drug at the end of 9 h and was considered as best formulation. A short‐term stability study of the optimized formulation F5 was carried out at 40ºC for three months. The formulation was found to be intact when kept at the ambient condition of temperature and humidity.

Keywords: Ornidazole, dental strip, physical characterization, in vitro release, stability study, antibacterial study.


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