European Journal of Biomedical and Pharmaceutical Sciences

ACOUSTICAL STUDY OF ANTIDIABETIC SITAGLIPTIN PHOSPHATE DRUG IN DMSO-WATER MIXTURES AT DIFFERENT TEMPERATURES

Shweta Pendse*, Hemant Jahagirdar and Mahesh Kumar Yenkie

ABSTRACT

liquid mixture provides valuable information about the physico-chemical properties and molecular interactions in solution. In light of pharmaceutical significance of sitagliptin phosphate, the acoustical properties adiabatic compressibility (κs), intermolecular free length (Lf), specific acoustic impedance (Z), relative association (RA) have been calculated from measured sound velocities (u) and densities (ρ) of ternary mixtures containing the said drug in aqueous-dimethyl sulfoxide mixtures have been carried out at 20vol% interval of the cosolvent at at 303.15, 308.15 and 313.15 K by standard methods. These derived properties are studied to understand the changes in molecular interactions between water and dimethyl sulfoxide and interpret the effect of drug concentration and temperature on the solvent structure and solute-solvent interactions. KEYWORDS: Ultrasonic velocity, molecular interaction,

Keywords: Ultrasonic velocity, molecular interaction, sitagliptin, dimethyl sulfoxide, adiabatic compressibilities.