Abstract
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL AND ANALGESIC EVALUATION OF NOVEL BENZOTHIAZOLES AGENTS

P. S. Raghu*

ABSTRACT

Five series of benzothiazole moieties were efficiently synthesized and evaluated for antimicrobial and anticancer activities. The results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms and showed higher activity against fungi than bacteria. Compounds BT-02 exhibited the greatest antimicrobial activity. Preliminary study of the structure–activity relationship revealed that electronic factors in benzothiazole rings had a great effect on the antimicrobial activity of these compounds. .The analgesic activity of compounds performed by using tail immersion method. in this case, compound BT-02 shows activity at 100 mg/kg dose 46 ± 0.22, 51 ± 0.22,58 ± 0.43, 48 ± 0.27 at time interval of 30 min,1 hour,2 hour,3 hour respectively compare with the other compounds due to the greater electronic effects.

Keywords: Benzthiazole, Anti Microbial Activity, Tail Immersion Method.


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