COMPARISON OF CLINICAL RESPONSE BETWEEN SIX AND EIGHT CYCLES OF CHOP CHEMOTHERAPY IN NON HODGKIN LYMPHOMA
Eldirdiri M. Abdel Rahman, Enaam A. Abdel Gadir, Ekhlas A. A. Ahmed and Sana E. Abdalla*
ABSTRACT
Background: Non Hodgkin lymphoma is one of the ten most common cancers in the developed world, it is one of the commonest malignancies in Sudan. There are a lot of treatment modalities used. This study is conducted to compare clinical response to six and eight cycles of CHOP chemotherapy among adult Sudanese patients with Non-Hodgkin lymphoma. Methods: Sixty five patients above 18 years of age with Non-Hodgkin lymphoma, attending oncology hospital from June to August 2016, treated with either six or eight cycles of CHOP chemotherapy recruited for this study. These patients have been followed up for six months. The data were collected using a standard structured questionnaire. The collected data were analyzed by SPSS software (version 19). Results: There was a significant difference in clinical responses of B symptoms, lymphadenopathy and splenomegaly between six and eight cycles of CHOP chemotherapy. In observing hepatomegaly, no significant difference was observed in response to CHOP after both six & eight cycles. Conclusion: This study concluded that, regarding the lymphadenopathy, splenomegaly and B symptoms (fever, sweating and weight loss), there was a marked improvement after eight cycles.
Keywords: Non Hodgkin Lymphoma, lymphadenopathy, spleenomegaly, Lymphoma, CHOP, Chemotherapy.
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