European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF HYPOLIPIDEMIC EFFECT OF VARIOUS EXTRACTS OF WHOLE PLANT OF ClerodendrumPaniculatum IN RAT FED WITH HIGH FAT DIET

C.D.Shaji Selvin * and Rakhi A.R.

ABSTRACT

The aim of the present study was to investigate the effect of the methanolic extract of leaves of Clerodendrum Paniculatum in reducing the cholesterol levels in experimentally induced hyperlipidemic rats. The acute toxicity study was found that methanolic extract was safe up to 2000mg/kg, so one tenth of this dose was consider as evaluation dose. The methanolic extract of Clerodendrum Paniculatum was administered in single doses of 200mg/kg/day and double dose of 400mg/kg/day to rats fed with high fat diet to assess its possible lipid-lowering potential.The elevated levels of total cholesterol, ester & free cholesterol, phospholipids, triglycerides, lowdensity lipoprotein, and very low-density lipoprotein due to HFD. Administration of methanolic extract of Clerodendrum Paniculatum(400mg/kg)was significantly (P<0.001)reduced the lipid profile and lipoprotein levels. A significant reduction in HDLcholesterol was noticed in HFD fed groups (II); however, a significant increased the HDL level was produced by the administration of methanolic extract of Clerodendrum Paniculatum (dose 400mg/kg). There was a noticed increase in the body weight in HFD fed group (II), which was reduced by the administration of methanolic extract of Clerodendrum Paniculatum(dose 400mg/kg).The methanolic extract of Clerodendrum Paniculatum could protect against atherosclerosis and decrease the atherogenic index Therefore, it was concluded that the methanolic extract of leaves of Clerodendrum Paniculatumhas definite cardio protective effect against hyperlipidemia.

Keywords: Clerodendrum Paniculatum, hyperlipidemic effect, HFD.