European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCH OF BISOPROLOL FUMARATE BY MERCURY SUBSTRATE METHOD

Singh Kehar*, Singh Satbir and Rana Arpana

ABSTRACT

Bisoprolol is a cardio selective β-blocker. It is given as the fumarate in the management of hypertension and angina pectoris. On oral administration, the drug under goes extensive first pass metabolism. Delivery of bisoprolol via transdermal route would minimize some of the deficiencies associated with the oral delivery and increase the bioavailability of the drug. In the present study, matrix type transdermal patches containing bisoprolol were prepared using different ratios of Ethylcellulose (EC) and Eudragit RL-100 by mercury substrate method. In vitro diffusion studies were performed for all formulations and in vitro skin permeation studies were performed for selected formulations on Pig skin by using Franz type diffusion cell. Diffused drug was quantified by UV-Spectrophotometer at 223 nm in phosphate buffer. The possible drug and polymer interaction was studied by IR Specrtoscopy. All the formulations were subjected to physicochemical studies such as weight variation, thickness, drug content, moisture uptake, moisture loss and folding endurance.

Keywords: Transdermal patch, Bisoprololfumarate, in-vitro diffusion.