FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF METOCLOPRAMIDE HYDROCHOLRIDE
Swati Mishra*, Neelesh Choubey and Harish Pandey
ABSTRACT
The skin can be used as the site for drug administration for continuous transdermal drug infusion into the systemic circulation. For the continuous diffusion/penetration of the drugs through the intact skin surface membrane-moderated systems, matrix dispersion type systems, adhesive diffusion controlled systems and micro reservoir systems have been developed. In the present work, an attempt has been made to develop a matrix-type transdermal therapeutic system comprising of Metoclopramide-HCl with different ratios of hydrophilic and hydrophobic polymeric combinations using solvent evaporation technique. The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy. The results obtained showed no physical-chemical incompatibility between the drug and the polymers. The patches were further subjected to various physical evaluations along with the in-vitro permeation studies using rat skin. On the basis of results obtained from the in-vitro study and physical evaluation of the patches. The drug release study and permeation studies of matrix films showed that cumulative % drug released (% CDR) and cumulative % drug permeation (% CDP) were observed to be increased, on increasing concentration of hydrophilic polymer while decreasing concentration of lipophilic polymer decreased % cumulative drug release and % cumulative drug permeation respectively were obtained. By using lipophilic polymer along with hydrophilic polymer combination, release rate and permeation rate can be achieved in controlled manner for longer time period.
Keywords: Metoclopramide, Transdermal Film, Permeation enhancer.
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