European Journal of Biomedical and Pharmaceutical Sciences

STUDY TO EVALUATE THE EFFECT OF HIGH FAT INDIAN MEAL ON POST PRANDIAL LIPID PROFILE IN PEOPLE WITH TYPE 2 DIABETES

*Kavita S. Gupta, Sabiha A. Vali, Sunil Gupta and Dr. Sachin Gathe

ABSTRACT

Post-prandial hypertriglyceridemia and hyperglycemia may jointly trigger spikes of oxidative stress, causing undetermined risk of atherosclerosis in people with type 2 diabetes(T2DM). We studied the effect of standardized high fat, calorie dense Indian food on lipid profile of people with T2DM and non-diabetics. 44 age, sex and BMI matched subjects [22 T2DM (DM group) and 22 non-diabetics (Non-DM group)] were selected. Postprandial lipid and glucose response was observed at baseline/0hour, 2hr, 4hr and 6hr after a fat tolerance test (FTT) using weight-adjusted Indian meal consisting of 70% fat, 5% protein and 25% carbohydrates. Mean total cholesterol, LDL-C and HDL-C between two groups differed insignificantly at each time point (P > 0.05) and across times. Mean triglyceride(TG) was significantly higher across time points in both groups (P<0.001) with peak at 4 hour. Mean TG at 4 hr and 6 hr, was significantly higher in DM versus Non-DM with P=0.033 and 0.047 respectively. At 6 hr, the mean TG level was close to 2 hr and was still significantly higher than baseline level (P<0.001). In Non-DM, mean TG at 6 hour was higher than baseline (P=0.005); however, it was close to acceptable level of 150mg/dl, indicating delayed clearance of TG in T2DM at 6hours. Conclusion: After high fat meal, post-prandial hypertriglyceridemia peak was seen at four hour, further more, there was significant delay in postprandial TG clearance at six hours. Postprandial hypertriglyceridemia with hyperglycemia, might pose additive cardiovascular risk amongst Indian T2DM.

Keywords: Type 2 Diabetes Mellitus, Postprandial Hypertriglyceridemia, Hyperglycaemia, High Fat Diet, India.