ANTI-OXIDANT AND ANTICANCER PROPERTIES OF ETHANOL LEAVES EXTRACT OF ERYTHRINA INDICA
R. Priya, P. Mani and S. Maneemegalai*
ABSTRACT
The aim of the study was to explore the pharmacological importance of the ethanol leaves extract of Erythrina indica. The dried leaves of this plant were extracted with ethanol; rotary evaporated and lyophilized which was used for antioxidant and anticancer properties. Antioxidant activities based on hydrogen peroxide scavenging assay showed most appreciable results of 83.6%, nitric oxide radical scavenging assay showed a moderate activity of 66.1%, moreover DPPH photometric assay and Superoxide radical scavenging assay showed least values of 21.7% and 19.7%. Further, the extract also revealed promising anticancer activity against the adenocarcinomic human alveolar basal epithelial cancer cells (A549) which showed concentration dependent activities and at the maximum tested concentrations of 1000μg/ml, it showed 78.89% cytotoxicity. All the above predictions proved that the ethanol extract from Erythrina indica showed significant results on both anticancer and antioxidant activities which will be useful for its application in near future in the field of biomedicine.
Keywords: Erythrina indica; Antioxidant; Anticancer; Leaves extract; Ethanol extraction; A549 cell line.
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