SERUM URIC ACID LEVELS IN TYPE 2 DIABETES MELLITUS WITH HYPERTENSION - A STUDY IN A TERTIARY CARE HOSPITAL OF NORTH-EAST INDIA
Avinanda Mahanta*, Kailash Bhattachryya and Abhijit Kalita
ABSTRACT
Introduction: Type 2 Diabetes Mellitus (T2DM) is the predominant form of diabetes worldwide, accounting for 90% of cases globally. DM and hypertension are interrelated diseases that strongly predispose an individual to atherosclerotic cardiovascular disease. In few studies some association has been found between the blood glucose and the serum uric acid (UA) levels. Hyperuricemia is also found to be associated with hypertension. This study was done to evaluate the relationship of serum UA levels in patients with T2DM and hypertension compared to that with healthy controls in a tertiary care hospital of North-East India. Method: A total of 200 individuals were used for this study. 50 individuals were established hypertensive diabetics and 50 were non-hypertensive diabetics, 50 individuals were hypertensive non-diabetics and 50 were normal healthy individuals (non-hypertensive and non-diabetics). Demographic data (age, sex, weight, height) were determined by appropriate method, medical records and proper history taking. Clinical examination was done. Blood samples were collected by proper methods. Plasma glucose and serum UA levels were determined by using auto analyzer. Results: The results showed that the mean level of UA was significantly higher (p< 0.05) in established hypertensive diabetes compared to non-hypertensive diabetes. It was observed that uric acid was also higher (p> 0.05) in hypertensive non diabetes individuals compared with normal healthy individuals studied. Conclusion: It was concluded from the study that there occurs a significant increase in the serum UA levels in hypertensive diabetics in comparison with the non-hypertensive diabetics.
Keywords: Diabetes, Hypertension, Uric acid, North-East India.
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