European Journal of Biomedical and Pharmaceutical Sciences

OSTEOPROTECTIVE EFFECT OF DIFFERENT COMPONENTS OF MORINGA OLIEFERA IN OVARIECTOMY INDUCED OSTEOPOROSIS MODEL OF WISTAR RATS

Pragna Parikh*, Chirag Patel and Ayaz Rangrez

ABSTRACT

Osteoporosis is a bone condition defined by low bone mass, increased fragility, decreased bone quality, and an increased fracture risk. Due to lack of compliance in current pharmacological interventions targeting bone problems like postmenopausal osteoporosis, there is an urge for developing new alternative therapies for osteoporosis. In recent times, interest has been given to phytotherapy due their ease of availability and acquiescence. Hence, the present study demonstrates that supplementing ovariectomized (OVX) animals with Moringa oliefera (MO) flower. leaf and fruit extract have positive effect on bone health. Following ovariectomy there was a dramatic decrease in the serum calcium levels, with an increase in the excretion of calcium. Elevated TRAcP and ALP after OVX decreased with MO extract exposure, fall in both the markers clearly suggest that MO plant extract ameliorate the damage caused by estrogen deficiency. Further, phytochemical analysis showed an array of phytochemicals with anti inflammatory as well as antioxidant properties, proving its osteoprotective efficacy. In general, the presence of these Phytochemicals could account for the much touted medicinal properties. Because of the chemical complexity of the MO, one individual phytochemical cannot be given the credit for its pharmacological property. Some compounds may be collectively affecting broad aspects of physiology, detoxification mechanisms, reducing the stress and re-supplementing the lost hormones such as phytoestrogens.

Keywords: Osteoporosis, Phytochemicals, Ovariectomy, Moringa Oliefera.