European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF LOSARTAN POTASSIUM NANOEMULSION GEL

S. Santosh Kumar*, Dr. C. Aparna and Dr. M. Bhagavan Raju

ABSTRACT

Aim & objective: The aim of the study was to develop nanoemulsion gel for transdermal delivery of Losartan potassium to enhance its bioavailability. Methods: O/W Nanoemulsions were prepared by the spontaneous emulsification method. IPM was chosen as the oil phase, Tween 80, Transcutol-P were used as surfactant and cosurfactant respectively, on the basis of solubility studies and emulsification studies in the formulation of nanoemulsion. Pseudoternary phase diagrams were constructed to obtain the nanoemulsion region. Further optimized NE was incorporated into 0.5% Carbopol-934 to get a gel for improving convenience in superficial application of the drug. Drug loaded NE and NEG were characterized for particle size, viscosity, rheological behavior, thermodynamic stability studies. Results: The optimized formulation was compared to conventional gel formulation and it showed higher permeation rate in-vitro and ex-vivo which justifies the nanoemulsion gel to be a promising carrier for transdermal delivery of losartan potassium. Conclusion: The optimized formulation showed higher drug release of 90.2%, compared to conventional gel that released 68.2% release in about 9 hrs. The study suggested that nanoemulsion significantly enhanced bioavailability of transdermally applied Losartan potassium.

Keywords: LP-Losartan Potassium, NE-Nanoemulsion, NEG- Nanoemulsion Gel.